Category Archives: Updated 2025

The Biochemists Songbook MP3 Files

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The Biochemists Songbook MP3 Files has a new home

http://www.csulb.edu/~cohlberg/songbook.html

https://sites.google.com/view/biochemists-songbook

or

https://www.csulb.edu/chemistry-biochemistry/page/jeffrey-cohlberg-phd

Michaelis reaction

The Michaelis-Arbuzov reaction is initiated with the SN2 reaction of the nucleophilic phosphite with the electrophilic alkyl halide to give a phosphonium intermediate. Triaryl phosphites, which are unable to perform the second step of the Michaelis-Arbuzov reaction, have been shown to produce stable phosphonium salts.Likewise, aryl and vinyl halides are unreactive towards phosphites.

The displaced halide anion reacts via another SN2 reaction with the phosphonium intermediate to give the desired phosphonate and another alkyl halide.

When chiral phosphonium intermediates are produced, it has been shown the halide substitution proceeds with inversion of configuration, as expected by a SN2 reaction.

I used to understand this…. not anymore…

Updated 2025, thanks Jeff

id Aromatics Retail and Wholesale Essential Oils

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IdAromatics, 12 New Station Street, Leeds

http://www.idaromatics.co.uk/


Id Aromatics is somewhat of an Institution in Leeds. It has been going for over twenty years, long before aromatherapy became popular. It was originally on Briggate and if my memory serves me correctly, started trading in 1983.

You can smell Id Aromatics from nearly 50 meters away and the pleasant odours emanating from within intrigued me so I followed my nose and went in.

The inside of the shop is a bit of an Aladdin’s cave and I’ve always found the staff to be helpful.

There is a minimum order of £35 from the website

Update (2021): Glad to see that Id is still there.

Update (2025): No longer there, but still can be placed online